IIT-M into unearthing the link
S Vishnu Sharmaa, INN/Chennai, @Svs037
There is no end to doing something useful at Indian Institute of Technology-Madras (IIT-M). This has turned true once again with researchers at the popular organisation have unearthed the link between tissue-remodelling enzyme ‘MMP7’ and hypertension.
Sources say, the research was taken up by a team under the leadership of Professor Nitish R. Mohapatra, Department of Biotechnology Bhupat and Jyoti Mehta School of Biosciences, IIT Madras. The Results were recently published in the reputed peer-reviewed journal Hypertension.
This study was carried out in collaboration with Translational Health Science and Technology, Faridabad, CSIR-Indian Institute of Chemical Biology, Kolkata, PGIMER-Chandigarh and Madras Medical Mission, Chennai.
The research paper has been co-authored by Dr. Lakshmi Subramanian, Ms. Sakthisree Maghajothi, Mr. Mrityunjay Singh, Dr. Kousik Kesh, Dr. Ananthamohan Kalyani, Mr. Saurabh Sharma, Dr. Madhu Khullar, Dr. Suma M. Victor, Dr. Snehasikta Swarnakar, Dr. Shailendra Asthana, Dr. Ajit S. Mullasari, and Professor Nitish Mahapatra.
Nitish Mahapatra said the study helps us understand the role of variations and functional regulatory changes in MMP7 gene promoter in increasing risk of cardiovascular disease among individuals.
This understanding will help us embark on preventive strategies for individuals carrying the variation that could lead to hypertension and related cardiovascular complications, he said.
Blood levels of a particular type of MMP called ‘MMP7’ has been found to be elevated in the event of hypertension, cardiovascular diseases and other metabolic syndrome group of ailments such as diabetes mellitus.
An earlier study has shown that knocking down MMP7 can reduce hypertension in rats. Structural changes in MMP7 gene, have been associated with coronary artery disease, acute myocardial infarction, multiple sclerosis, rheumatoid arthritis, and several cancers.
However, the connection between variations in the MMP7 gene and hypertension has hitherto not been well-understood.
Dr. Mahapatra’s team studied the association of an MMP7 gene promoter with hypertension in two geographically distinct Indian populations – North and South Indians.
They found that a change in the regulatory region of the MMP7 gene showed strong association with increased hypertension risk. People with these changes also had increased blood MMP7 levels and high blood pressure, which suggested that this change in the gene may contribute to cardiovascular risk.
The team also dissected the cellular and molecular mechanisms behind the increased blood MMP7 levels in the carriers of this genetic variation.
Hypertension, a common disease in India, is associated with remodelling of heart tissues. Matrix metalloproteinases (MMPs) play a crucial role in such hypertension-induced heart tissue remodelling, which results in alterations in the structural and mechanical support to blood vessels. This directly results in increased risk for cardiovascular diseases.
